https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44996 Batrachochytrium dendrobatidis is an emerging infectious pathogen present on every continent except Antarctica. It causes the disease chytridiomycosis in a subset of species but does not always result in disease or death for every host. Ambient temperature influences both amphibian metabolism and chytrid pathogenicity, however the interactive effects on host physiology is not well understood. We investigated the sublethal effect of B. dendrobatidis infection on a susceptible host, Litoria aurea to test (1) whether the infection load, metabolic activity, body fat and gonad size differed in L. aurea at either 24 °C or 12 °C ambient temperatures and (2) whether previous Bd infection caused long-term changes to body fat and gonad size. Litoria aurea in 12 °C treatments had higher infection loads of B. dendrobatidis and lower survivorship. Metabolic rate was higher and fat mass was lower in infected individuals and in animals in 24 °C treatments. Male L. aurea previously infected with B. dendrobatidis had smaller testes 5 months-post clearance of infection, an effect likely to translate to fitness costs in wild populations. These experiments demonstrate a physiological cost to sublethal B. dendrobatidis infection, which suggests a reduction in host fitness mediated by temperature in the host’s environment regardless of whether infection leads to mortality.]]> Wed 26 Oct 2022 09:28:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43222 Wed 14 Sep 2022 15:44:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12741 Wed 11 Apr 2018 16:32:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14135 Wed 11 Apr 2018 15:35:24 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49343 Thu 11 May 2023 15:52:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32799 Thu 09 Dec 2021 11:02:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32780 Thu 03 Feb 2022 12:18:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42707 Thu 01 Sep 2022 09:55:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8245 Sat 24 Mar 2018 08:40:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19456 Sat 24 Mar 2018 08:02:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17307 Sat 24 Mar 2018 08:01:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27929 Mon 20 Mar 2023 12:45:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47905 5 years postdiagnosis. Parents reported on their child's HRQoL (Kidscreen-10), and their own HRQoL (EQ-5D-5L). Parents rated their resilience and fear of cancer recurrence and listed their child's cancer-related late effects. Results: One hundred eighty-two parents of survivors (mean age = 12.4 years old and 9.7 years postdiagnosis) participated. Parent-reported child HRQoL was significantly lower than population norms (48.4 vs. 50.7, p < .009). Parents most commonly reported that their child experienced sadness and loneliness (18.1%). Experiencing more late effects and receiving treatments other than surgery were associated with worse child HRQoL. Parents’ average HRQoL was high (0.90) and no different to population norms. However 38.5% of parents reported HRQoL that was clinically meaningfully different from perfect health, and parents experienced more problems with anxiety/depression (43.4%) than population norms (24.7%, p < .0001). Worse child HRQoL, lower parent resilience, and higher fear of recurrence was associated with worse parent HRQoL. Conclusions: Parents report that young survivors experience small but significant ongoing reductions in HRQoL. While overall mean levels of HRQoL were no different to population norms, a subset of parents reported HRQoL that was clinically meaningfully different from perfect health. Managing young survivors’ late effects and improving parents’ resilience through survivorship may improve HRQoL in long-term survivorship.]]> Mon 06 Feb 2023 15:07:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36960 Mon 03 Jul 2023 14:35:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53869 Fri 19 Jan 2024 12:38:22 AEDT ]]>